Chapter Author
Christopher
de Solis, PhD.

Dr. Christopher de Solis is a Molecular Biologist with over 16 years of experience in aging research, genetics, gene therapy, and disease models. He developed an early interest in aging research during his undergraduate studies at Temple University, investigating models of infant amnesia, stress, and neurodegeneration in the aging brain in the laboratory of Dr. Diana Woodruff-Pak. Christopher then went on to work in the laboratory of Dr. Douglas Wallace at the University of Pennsylvania, where he investigated the mechanisms behind mitochondrial DNA (mtDNA) mutations and maternal inheritance of mtDNA in the aging brain.
Obtaining his Ph.D. from The University of Texas, Dr. de Solis published pioneering work on genetic medicine in the laboratory of Dr. Jonathan Ploski. He performed critical toxicology assessments following gene delivery with viral vectors and optimized gene editing systems, publishing some of the first evidence of in vivo gene editing in mammals using CRISPR/Cas delivered by vectors utilized for gene therapy.
Christopher completed his postdoctoral research at the Howard Hughes Medical Institute and Columbia University in the laboratory of Dr. Eric Kandel, the famed author and researcher who was the recipient of the Nobel Prize in Medicine for his work in neurotransmission and nucleus-synapse signaling. There, Christopher studied the aging brain, mechanisms of functional prions, and developed novel genetic tools to dissect brain function. He then applied his skills in aging research and genetic medicine to prevent and treat diseases of aging in humans and companion animals at Rejuvenate Bio and Matter Bio, both companies spun out of the laboratory of renowned Harvard geneticist George Church.