Matt Yousefzadeh, Ph.D., is an Assistant Professor in the Department of Medicine at Columbia University Irving Medical Center and is a member of the Columbia Center for Translational Immunology and the Burch-Lodge Center for Human Longevity. Dr. Yousefzadeh’s laboratory utilizes in vitro and in vivo models of aging to explore the effect of senescent cells, in particular senescent immune cells, on driving organismal aging. The mechanistic studies of cell and cell non-autonomous effects provide insight into interorgan communication and how different pillars of aging can serve to drive aging in a tissue or cell type-specific manner. Using samples from humans and animal models of aging, the laboratory focuses on developing useful biomarkers of aging with translational potential. Lastly, the laboratory uses models of natural aging, accelerated aging, and preclinical models of disease to test the efficacy of geroprotective compounds like senolytics.