Dr. Brandhorst's training is based on a background in cell biology, molecular biology, medicine, and biochemistry, all of which are highly relevant for his focus on biogerontology research to identify the mechanisms underlying health- and lifespan-regulation, and their translation into clinical applications. Sebastian has performed research related to aging in mouse models to study the role of growth hormone/Insulin-like growth factor 1 (IGF-1) signaling as a major regulatory pathway that modulates lifespan and age-associated diseases/pathologies; particularly cancer. Subsequently, he focused on the role and application of short-term starvation, low calorie and/or low protein diets, so called fasting-mimicking diets, on health- and lifespan in pre-clinical and clinical studies.